RNAi drugs: Next generation drugs?

Expected Next-Generation Drugs

Hypercholesterolaemia: optimal treatment by next-generation drugs?

ticular, homozygous autosomal dominant hypercholesterolaemia, an orphan disease caused by mutations in the LDL receptor, apolipoprotein B (APOB), or PCSK9, is characterised by elevated LDL-C levels [8]. At the same time as the approval of evolocumab, the US Food and Drug Administration (FDA) approved another PCSK9 inhibitor, alirocumab (Praluent) produced by Sanofi and Regeneron. Alirocumab was...

Research on Drugs - Crime Linkages : The Next Generation

The association between drugs and crime in the public mind is so strong that a recent psychology experiment showed the word “drug” tightly linked to such words as “choke,” “knife,” “fight,” and “wound” in participants’ associative memory networks (Bushman, 1996). Although it is routine in academia to deride public ignorance of all things criminological, in this case the public is hardly deluded...

Antithyroid Drugs

The thionamide drugs, i.e. carbimazole and its metabolite methimazole (MMI), andpropylthiouracil (PTU) have extensively been used in the management of various forms ofhyperthyroidism over the past eight decades. This review aims to summarize different aspectsof these outstanding medications. Thionamides have shown their own acceptable efficacy andeven safety profiles in ...

Antithyroid Drugs

The thionamide drugs, i.e. carbimazole and its metabolite methimazole (MMI), andpropylthiouracil (PTU) have extensively been used in the management of various forms ofhyperthyroidism over the past eight decades. This review aims to summarize different aspectsof these outstanding medications. Thionamides have shown their own acceptable efficacy andeven safety profiles in ...